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Article

Solution structure of the transforming growth factor beta-binding protein-like module, a domain associated with matrix fibrils.

The EMBO journal - 17 Nov 1997

Yuan X, Downing A K, Knott V, Handford P A

Abstract excerpt

Here we describe the high resolution nuclear magnetic resonance (NMR) structure of a transforming growth factor beta (TGF-beta)-binding protein-like (TB) domain, which comes from human fibrillin-1, the protein defective in the Marfan syndrome (MFS). This domain is found in fibrillins and latent TGF-beta-binding proteins (LTBPs) which are localized to fibrillar structures in the extracellular matrix. The TB domain...

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Identifiers

PMID: 9362480
DOI: 10.1093/emboj/16.22.6659
PMCID: PMC1170270

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