Article
HLA DQ gene dosage and risk and severity of celiac disease.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Dec 2007
Murray Joseph A, Moore S Breanndan, Van Dyke Carol T, Lahr Brian D, Dierkhising Ross A, Zinsmeister Alan R, Melton L Joseph, Kroning Cynthia M, El-Yousseff Mounif, Czaja Albert J
Abstract excerpt
BACKGROUND & AIMS: Celiac disease (CD) is a chronic inflammatory disorder of the small intestine that is strongly associated with certain HLA molecules encoded by DQA and DQB genes. The aim of this study was to examine the role of DQA and DQB alleles in determining the risk for and the age of onset and severity of CD in an American population. METHODS: High-resolution class 2 HLA genotyping was performed in a...
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