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Celiac disease risk stratification based on HLA-DQ heterodimer (HLA-DQA1 ~ DQB1) typing in a large cohort of adults with suspected celiac disease.

Human immunology - 1 Jan 2000

Choung Rok Seon, Mills John R, Snyder Melissa R, Murray Joseph A, Gandhi Manish J

Abstract excerpt

BACKGROUNDS: Patients with celiac disease (CeD) carry the major histocompatibility complex class II, HLA-DQ2 or DQ8 haplotype; the absence of these haplotypes excludes a diagnosis of CeD. While the most common and highest risk HLA haplotypes in CeD have been established, the risk profiles of the less common and equivocal HLA haplotypes need further refinement. The aim of this study was to use a large national...

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PMID: 32005535
DOI: 10.1016/j.humimm.2020.01.006

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