Article
Escherichia coli HU protein has a role in the repair of abasic sites in DNA.
Nucleic acids research - 1 Jan 2007
Kow Yoke W, Imhoff Barry, Weiss Bernard, Hung David C I, Hindoyan Antreas A, Story Randall M, Goodman Steven D
Abstract excerpt
HU is one of the most abundant DNA binding proteins in Escherichia coli. We find that it binds strongly to DNA containing an abasic (AP) site or tetrahydrofuran (THF) (apparent K(d) approximately 50 nM). It also possesses an AP lyase activity that cleaves at a deoxyribose but not at a THF residue. The binding and cleavage of an AP site was observed only with the HUalphabeta heterodimer. Site-specific mutations at...
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