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Article

The thermostability of DNA-binding protein HU from mesophilic, thermophilic, and extreme thermophilic bacteria.

Extremophiles : life under extreme conditions - 1 Feb 2002

Christodoulou Evangelos, Vorgias Constantinos E

Abstract excerpt

Based on primary structure comparison between four highly homologous DNA-binding proteins (HUs) displaying differential thermostability, we have employed in vitro site-directed mutagenesis to decipher their thermostability mechanism at the molecular level. The contribution of the 11 amino acids that differ between the thermophilic HUBst from Bacillus stearothermophilus (Tm = 61.6 degrees C) and the mesophilic...

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Identifiers

PMID: 11878558
DOI: 10.1007/s007920100235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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