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Article

Chemokine CXCL12 enhances proliferation in pre‐B‐ALL via STAT5 activation

3 Oct 2007

Abstract excerpt

BACKGROUND: CXCL12 (SDF-1alpha) is a chemokine, which plays an important role in normal B-cell lymphopoesis, migration and homing to the bone marrow (BM) and previous studies have suggested a role for CXCL12 and its receptor CXCR4 in the pathogenesis of ALL. PURPOSE: CXCL12 levels in serum were evaluated from ALL-children and controls. The biological effect of recombinant CXCL12 on primary leukaemic cells was...

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PMID: 17914737
DOI: 10.1002/pbc.21370

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