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Article

Durable, Safe, Multi-gene Lentiviral Vector Expression in Feline Trabecular Meshwork

2 Oct 2007

Abstract excerpt

Multiple disease-specific considerations have led to interest in the potential of gene therapy to permanently correct elevated intraocular pressure (IOP), the main causal risk factor for primary open angle glaucoma (POAG). Since IOP elevation results from abnormal resistance to aqueous humor outflow from the eye through the trabecular meshwork (TM), a means to genetically modify this specialized outflow organ...

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PMID: 17912236
DOI: 10.1038/sj.mt.6300318

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