Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Modification of Human Trabecular Meshwork with Lentiviral Vectors

20 Nov 2001

Abstract excerpt

Glaucoma, a group of optic neuropathies, is the leading cause of irreversible blindness. Neuronal apoptosis in glaucoma is primarily associated with high intraocular pressure caused by chronically impaired outflow of aqueous humor through the trabecular meshwork, a reticulum of mitotically inactive endothelial-like cells located in the angle of the anterior chamber. Anatomic, genetic, and expression profiling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glaucoma and retinal disorders
Share to Retinal Development and Disorders
Share to Retinopathy of Prematurity Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11747600
DOI: 10.1089/10430340152677449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Modification of Human Trabecular Meshwork with Lentiviral VectorsPMID 11747600Read ↗

Durable, Safe, Multi-gene Lentiviral Vector Expression in Feline Trabecular MeshworkSemantic proximity Read ↗

Long-Term, Targeted Genetic Modification of the Aqueous Humor Outflow Tract Coupled with Noninvasive Imaging of Gene Expression In VivoSemantic proximity Read ↗

Prolonged Transgene Expression with Lentiviral Vectors in the Aqueous Humor Outflow Pathway of Nonhuman PrimatesSemantic proximity Read ↗

Mechanisms of AAV transduction in glaucoma‐associated human trabecular meshwork cellsSemantic proximity Read ↗

Gene Transfer to the Outflow TractSemantic proximity Read ↗

Elevation of intraocular pressure in rodents using viral vectors targeting the trabecular meshworkSemantic proximity Read ↗

Induced Pluripotent Stem Cells Restore Function in a Human Cell Loss Model of Open-Angle GlaucomaSemantic proximity Read ↗

Non-invasive observation of repeated adenoviral GFP gene delivery to the anterior segment of the monkey eyein vivoSemantic proximity Read ↗

Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of GlaucomaSemantic proximity Read ↗

Adenoviral Gene Transfer of Active Human Transforming Growth Factor-β2 Elevates Intraocular Pressure and Reduces Outflow Facility in Rodent EyesSemantic proximity Read ↗

Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat.Semantic proximity Read ↗

Stem cell transplantation rescued a primary open-angle glaucoma mouse modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.