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Article

Prostaglandin Pathway Gene Therapy for Sustained Reduction of Intraocular Pressure

1 Dec 2009

Abstract excerpt

Cyclooxygenase-2 (COX-2) is a rate-limiting enzyme in prostaglandin (PG) biosynthesis. In the eye, loss of COX-2 expression in aqueous humor-secreting cells has been associated with primary open-angle glaucoma (POAG). Reduction of intraocular pressure (IOP) is the main treatment goal in this disease. We used lentiviral vectors to stably express COX-2 and other PG biosynthesis and response transgenes in the...

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Identifiers

PMID: 19953083
DOI: 10.1038/mt.2009.278

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