Article
Copy-number variants in patients with a strong family history of pancreatic cancer.
Cancer biology & therapy - 1 Oct 2007
Lucito Robert, Suresh Shubha, Walter Kimberly, Pandey Akhilesh, Lakshmi B, Krasnitz Alex, Sebat Jonathan, Wigler Michael, Klein Alison P, Brune Kieran, Palmisano Emily, Maitra Anirban, Goggins Michael, Hruban Ralph H
Abstract excerpt
Copy-number variants such as germ-line deletions and amplifications are associated with inherited genetic disorders including familial cancer. The gene or genes responsible for the majority of familial clustering of pancreatic cancer have not been identified. We used representational oligonucleotide microarray analysis (ROMA) to characterize germ-line copy number variants in 60 cancer patients from 57 familial...
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