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Injection of Flagellin into the Host Cell Cytosol by Salmonella enterica Serotype Typhimurium

2 Oct 2007

Abstract excerpt

Bacterial flagellins are potent inducers of innate immunity. Three signaling pathways have been implicated in the sensing of flagellins; these involve toll-like receptor 5 (TLR5) and the cytosolic proteins Birc1e/Naip5 and Ipaf. Although the structural basis of TLR5-flagellin interaction is known, little is known about how flagellin enters the host cell cytosol to induce signaling via Birc1e/Naip5 and Ipaf. Here...

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PMID: 17911114
DOI: 10.1074/jbc.c700181200

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