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Article

Salmonella typhimurium transcytoses flagellin via an SPI2-mediated vesicular transport pathway.

Journal of cell science - 15 Nov 2004

Lyons Sean, Wang Lixin, Casanova James E, Sitaraman Shanthi V, Merlin Didier, Gewirtz Andrew T

Abstract excerpt

Apical colonization of polarized epithelia by Salmonella typhimurium results in translocation of flagellin to the basolateral membrane domain, thus enabling activation of toll-like receptor 5 (TLR5)-mediated pro-inflammatory gene expression. Such flagellin transcytosis occurred without a change in epithelial permeability to 40 kDa FITC dextran, did not require bacterial motility and was independent of...

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Identifiers

PMID: 15507487
DOI: 10.1242/jcs.01500

Genes

TLR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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