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Article

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf.

Nature immunology - 1 Jun 2006

Miao Edward A, Alpuche-Aranda Celia M, Dors Monica, Clark April E, Bader Martin W, Miller Samuel I, Aderem Alan

Abstract excerpt

Macrophages respond to Salmonella typhimurium infection via Ipaf, a NACHT-leucine-rich repeat family member that activates caspase-1 and secretion of interleukin 1beta. However, the specific microbial salmonella-derived agonist responsible for activating Ipaf is unknown. We show here that cytosolic bacterial flagellin activated caspase-1 through Ipaf but was independent of Toll-like receptor 5, a known flagellin...

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PMID: 16648853
DOI: 10.1038/ni1344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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