Article
Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response.
The Journal of clinical investigation - 1 Jan 2001
Gewirtz A T, Simon P O, Schmitt C K, Taylor L J, Hagedorn C H, O'Brien A D, Neish A S, Madara J L
Abstract excerpt
This study investigated whether soluble paracrine factors mediated Salmonella-induced IL-8 expression in polarized model intestinal epithelia. We found that the basolateral media of model epithelia that had been apically infected with Salmonella typhimurium for a short period (10 minutes) could activate IL-8 secretion in virgin model epithelia, demonstrating that a proinflammatory factor (PIF) was indeed present....
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