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Article

Tyrosine nitration of IkappaBalpha: a novel mechanism for NF-kappaB activation.

Biochemistry - 23 Oct 2007

Yakovlev Vasily A, Barani Igor J, Rabender Christopher S, Black Stephen M, Leach J Kevin, Graves Paul R, Kellogg Glen E, Mikkelsen Ross B

Abstract excerpt

The NF-kappaB family of transcription factors is an important component of stress-activated cytoprotective signal transduction pathways. Previous studies demonstrated that some activation mechanisms require phosphorylation, ubiquitination, and degradation of the inhibitor protein, IkappaBalpha. Herein, it is demonstrated that ionizing radiation in the therapeutic dose range stimulates NF-kappaB activity by a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nitric Oxide Synthase Type I

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Source

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Identifiers

PMID: 17910475
DOI: 10.1021/bi701107z
PMCID: PMC2678910

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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