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Article

PARP-1-dependent 3-nitrotyrosine protein modification after DNA damage.

Journal of cellular biochemistry - 1 Nov 2005

Siles E, Martinez-Lara E, Núñez M I, Muñoz-Gámez J A, Martín-Oliva D, Valenzuela M T, Peinado M A, Ruiz de Almodóvar J M, Javier Oliver F

Abstract excerpt

3-nitrotyrosine (NO2-Tyr) is thought to be a specific marker of cell injury during oxidative damage. We have evaluated the role of poly(ADP-ribose)polymerase-1 (PARP-1) in protein nitration after treatment of immortalized fibroblasts parp-1+/+ and parp-1-/- with the alkylating agent 2'-methyl-2'-nitroso-urea (MNU). Both cell lines showed increased iNOS expression following MNU treatment in parallel with a...

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PMID: 16052507
DOI: 10.1002/jcb.20570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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