Article
Inhibition of protein-tyrosine phosphatases by mild oxidative stresses is dependent on S-nitrosylation.
The Journal of biological chemistry - 15 Apr 2005
Barrett Daniel M, Black Stephen M, Todor Horia, Schmidt-Ullrich Rupert K, Dawson Kathryn S, Mikkelsen Ross B
Abstract excerpt
Previous studies have shown that a Ca(2+)-dependent nitric-oxide synthase (NOS) is activated as part of a cellular response to low doses of ionizing radiation. Genetic and pharmacological inhibitor studies linked this NO signaling to the radiation-induced activation of ERK1/2. Herein, a mechanism for the radiation-induced activation of Tyr phosphorylation-dependent pathways (e.g. ERK1/2) involving the inhibition...
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