Prevalence of clinically relevant UGT1A alleles and haplotypes in African populations.

doi:10.1111/j.1469-1809.2010.00638.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Prevalence of clinically relevant UGT1A alleles and haplotypes in African populations.

Annals of human genetics - 1 Mar 2011

Horsfall Laura J, Zeitlyn David, Tarekegn Ayele, Bekele Endashaw, Thomas Mark G, Bradman Neil, Swallow Dallas M

Abstract excerpt

Variation of a short (TA)(n) repeat sequence (rs8175347) covering the TATA box of UGT1A1 (UDP-glucuronosyltransferase1A1) is associated with hyperbilirubinaemia (Gilbert's syndrome) and adverse drug reactions, and is used for dosage advice for irinotecan. Several reports indicate that the low-activity (risk) alleles ((TA)(7) and (TA)(8) )) are very frequent in Africans but the patterns of association with other...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetics, Population

Share to Glucuronosyltransferase

Share to Haplotypes

Share to Hyperbilirubinemia

Share to Prevalence

Share to Promoter Regions, Genetic

Share to Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 21309756
DOI: 10.1111/j.1469-1809.2010.00638.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevalence of clinically relevant UGT1A alleles and haplotypes in African populations.PMID 21309756Read ↗

Pharmacogenetics of Gilbert's syndrome.Semantic proximity Read ↗

Family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A): from Gilbert's syndrome to genetic organization and variability.Semantic proximity Read ↗

UDP-Glucuronosyltransferase 1A1 gene polymorphisms and total bilirubin levels in an ethnically diverse cohort of women.Semantic proximity Read ↗

Clinically actionable UGT1A1 variants in black Zimbabwean cancer patients eligible for irinotecanSemantic proximity Read ↗

Mapping the Pharmacogenetic Landscape in a Ugandan Population: Implications for Personalized Medicine in an Underrepresented Population.Semantic proximity Read ↗

UGT1A1, UGT1A6 and UGT1A7 genetic analysis: repercussion for irinotecan pharmacogenetics in the São Miguel Island Population (Azores, Portugal).Semantic proximity Read ↗

Intra-ethnic differences in genetic variants of the UGT-glucuronosyltransferase 1A1 gene in Chinese populations.Semantic proximity Read ↗

Variability and function of family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A).Semantic proximity Read ↗

Bilirubin metabolism and UDP-glucuronosyltransferase 1A1 variants in Asians: Pathogenic implications and therapeutic response.Semantic proximity Read ↗

Variability at the uridine diphosphate glucuronosyltransferase 1A1 promoter in human populations and primates.Semantic proximity Read ↗

Comparison of Eight Technologies to Determine Genotype at the UGT1A1 (TA)n Repeat Polymorphism: Potential Clinical Consequences of Genotyping Errors?Semantic proximity Read ↗

Genetic variability, haplotypes, and htSNPs for exons 1 at the human UGT1A locus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.