Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Snail-Induced Down-Regulation of ΔNp63α Acquires Invasive Phenotype of Human Squamous Cell Carcinoma

1 Oct 2007

Abstract excerpt

p63 is a member of the p53 family and regulates crucial events in the formation of epithelial structures, but the role of p63 in tumor is unclear. We found that Snail-induced epithelial-to-mesenchymal transition (EMT) is accompanied by down-regulation of p63 in human squamous cell carcinomas (SCC). DeltaNp63alpha is the predominantly expressed p63 isoform in SCC cells. DeltaNp63 promoter activity required a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer-related Molecular Pathways
Share to Cancer Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17909026
DOI: 10.1158/0008-5472.can-07-0932

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Snail-Induced Down-Regulation of ΔNp63α Acquires Invasive Phenotype of Human Squamous Cell CarcinomaPMID 17909026Read ↗

ΔNp63α‐dependent expression of Id‐3 distinctively suppresses the invasiveness of human squamous cell carcinomaSemantic proximity Read ↗

Regulation of p63 Isoforms by Snail and Slug Transcription Factors in Human Squamous Cell CarcinomaSemantic proximity Read ↗

Regulation of VDR by ΔNp63α is associated with inhibition of cell invasionSemantic proximity Read ↗

ΔNp63 isoforms regulate CD44 and keratins 4, 6, 14 and 19 in squamous cell carcinoma of head and neckSemantic proximity Read ↗

The downregulation of ΔNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior.Semantic proximity Read ↗

Physical Association of HDAC1 and HDAC2 with p63 Mediates Transcriptional Repression and Tumor Maintenance in Squamous Cell CarcinomaSemantic proximity Read ↗

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.Semantic proximity Read ↗

Complex p63 mRNA isoform expression patterns in squamous cell carcinoma of the head and neckSemantic proximity Read ↗

ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced MetastasisSemantic proximity Read ↗

Tumor-Specific p73 Up-regulation Mediates p63 Dependence in Squamous Cell CarcinomaSemantic proximity Read ↗

ERK3 is transcriptionally upregulated by ∆Np63α and mediates the role of ∆Np63α in suppressing cell migration in Non-Melanoma Skin CancersSemantic proximity Read ↗

The p53 Homologue ΔNp63α Interacts with the Nuclear Factor-κB Pathway to Modulate Epithelial Cell GrowthSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.