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Article

ΔNp63α‐dependent expression of Id‐3 distinctively suppresses the invasiveness of human squamous cell carcinoma

21 Jan 2009

Abstract excerpt

p63 is a member of the p53 family and DeltaNp63alpha is the dominant-expressing isoform of p63 in basal layer of normal stratified epithelium and human squamous cell carcinoma (SCC) cells. We have previously reported that down-regulation of p63 was accompanied with epithelial-to-mesenchymal transition (EMT) by Snail-expressing SCC cells, in which re-expression of DeltaNp63alpha diminished their invasiveness...

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PMID: 19267405
DOI: 10.1002/ijc.24280

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