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Article

Epigenetic Inactivation of IκB Kinase-α in Oral Carcinomas and Tumor Progression

1 Sept 2007

Abstract excerpt

PURPOSE: The loss of epithelial phenotypes in the process of carcinoma progression correlates with clinical outcome, and genetic/epigenetic changes accumulate aggressive clones toward uncurable disease. IkappaB kinase-alpha (IKKalpha) has a decisive role in the development of the skin and establishes keratinocyte phenotypes. We assessed clinical implications of IKKalpha expression in oral carcinomas and...

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PMID: 17785555
DOI: 10.1158/1078-0432.ccr-07-0463

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Epigenetic Inactivation of IκB Kinase-α in Oral Carcinomas and Tumor ProgressionPMID 17785555Read ↗

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