Article
Growth control of Golgi phosphoinositides by reciprocal localization of sac1 lipid phosphatase and pik1 4-kinase.
Traffic (Copenhagen, Denmark) - 1 Nov 2007
Faulhammer Frank, Kanjilal-Kolar Suparna, Knödler Andreas, Lo Jennifer, Lee Yerim, Konrad Gerlinde, Mayinger Peter
Abstract excerpt
Compartment-specific control of phosphoinositide lipids is essential for cell function. The Sac1 lipid phosphatase regulates endoplasmic reticulum (ER) and Golgi phosphatidylinositol-4-phosphate [PI(4)P] in response to nutrient levels and cell growth stages. During exponential growth, Sac1p interacts with Dpm1p at the ER but shuttles to the Golgi during starvation. Here, we report that a C-terminal region in...
Topics
- 1-Phosphatidylinositol 4-Kinase
- Amino Acid Motifs
- Biological Transport
- Cross-Linking Reagents
- Endoplasmic Reticulum
- Gene Expression Regulation, Fungal
- Genotype
- Golgi Apparatus
- Green Fluorescent Proteins
- Microscopy, Fluorescence
- Models, Biological
- Mutagenesis