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Article

Growth control of Golgi phosphoinositides by reciprocal localization of sac1 lipid phosphatase and pik1 4-kinase.

Traffic (Copenhagen, Denmark) - 1 Nov 2007

Faulhammer Frank, Kanjilal-Kolar Suparna, Knödler Andreas, Lo Jennifer, Lee Yerim, Konrad Gerlinde, Mayinger Peter

Abstract excerpt

Compartment-specific control of phosphoinositide lipids is essential for cell function. The Sac1 lipid phosphatase regulates endoplasmic reticulum (ER) and Golgi phosphatidylinositol-4-phosphate [PI(4)P] in response to nutrient levels and cell growth stages. During exponential growth, Sac1p interacts with Dpm1p at the ER but shuttles to the Golgi during starvation. Here, we report that a C-terminal region in...

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Identifiers

PMID: 17908202
DOI: 10.1111/j.1600-0854.2007.00632.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Growth control of Golgi phosphoinositides by reciprocal localization of sac1 lipid phosphatase and pik1 4-kinase.PMID 17908202Read ↗

Cell growth-dependent coordination of lipid signaling and glycosylation is mediated by interactions between Sac1p and Dpm1p.Semantic proximity Read ↗

Nucleocytoplasmic shuttling of the Golgi phosphatidylinositol 4-kinase Pik1 is regulated by 14-3-3 proteins and coordinates Golgi function with cell growth.Semantic proximity Read ↗

Retention of the yeast Sac1p phosphatase in the endoplasmic reticulum causes distinct changes in cellular phosphoinositide levels and stimulates microsomal ATP transport.Semantic proximity Read ↗

Regulation of intracellular phosphatidylinositol-4-phosphate by the Sac1 lipid phosphatase.Semantic proximity Read ↗

The yeast phosphatidylinositol-4-OH kinase pik1 regulates secretion at the Golgi.Semantic proximity Read ↗

Requirement for Golgi-localized PI(4)P in fusion of COPII vesicles with Golgi compartments.Semantic proximity Read ↗

Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterolSemantic proximity Read ↗

Oxysterol-binding protein recruitment and activity at the endoplasmic reticulum-Golgi interface are independent of Sac1.Semantic proximity Read ↗

The Sac1 phosphoinositide phosphatase regulates Golgi membrane morphology and mitotic spindle organization in mammals.Semantic proximity Read ↗

Synthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a Golgi-specific Ypt31/rab-GTPase signaling pathway.Semantic proximity Read ↗

Orm proteins integrate multiple signals to maintain sphingolipid homeostasis.Semantic proximity Read ↗

TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.Semantic proximity Read ↗

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