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Article

Requirement for Golgi-localized PI(4)P in fusion of COPII vesicles with Golgi compartments.

Molecular biology of the cell - 15 Jan 2011

Lorente-Rodríguez Andrés, Barlowe Charles

Abstract excerpt

The role of specific membrane lipids in transport between endoplasmic reticulum (ER) and Golgi compartments is poorly understood. Using cell-free assays that measure stages in ER-to-Golgi transport, we screened a variety of enzyme inhibitors, lipid-modifying enzymes, and lipid ligands to investigate requirements in yeast. The pleckstrin homology (PH) domain of human Fapp1, which binds...

Topics

Adaptor Proteins, Signal Transducing
COP-Coated Vesicles
Golgi Apparatus
Humans
Intracellular Membranes
Membrane Fusion
Membrane Proteins
Mutation
Phosphatidylinositol Phosphates
Phosphoric Monoester Hydrolases
Protein Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Proteins

SNARE Proteins

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21119004
DOI: 10.1091/mbc.E10-04-0317
PMCID: PMC3020917

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21119004-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Requirement for Golgi-localized PI(4)P in fusion of COPII vesicles with Golgi compartments.PMID 21119004Read ↗

Regulation of intracellular phosphatidylinositol-4-phosphate by the Sac1 lipid phosphatase.Semantic proximity Read ↗

Cell growth-dependent coordination of lipid signaling and glycosylation is mediated by interactions between Sac1p and Dpm1p.Semantic proximity Read ↗

Growth control of Golgi phosphoinositides by reciprocal localization of sac1 lipid phosphatase and pik1 4-kinase.Semantic proximity Read ↗

The yeast phosphatidylinositol-4-OH kinase pik1 regulates secretion at the Golgi.Semantic proximity Read ↗

Nucleocytoplasmic shuttling of the Golgi phosphatidylinositol 4-kinase Pik1 is regulated by 14-3-3 proteins and coordinates Golgi function with cell growth.Semantic proximity Read ↗

Synthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a Golgi-specific Ypt31/rab-GTPase signaling pathway.Semantic proximity Read ↗

Retention of the yeast Sac1p phosphatase in the endoplasmic reticulum causes distinct changes in cellular phosphoinositide levels and stimulates microsomal ATP transport.Semantic proximity Read ↗

Characterization of Pik1 function in fission yeast reveals its conserved role in lipid synthesis and not cytokinesisSemantic proximity Read ↗

The clathrin adaptor Gga2p is a phosphatidylinositol 4-phosphate effector at the Golgi exit.Semantic proximity Read ↗

Synthesis of sphingolipids with very long chain fatty acids but not ergosterol is required for routing of newly synthesized plasma membrane ATPase to the cell surface of yeast.Semantic proximity Read ↗

Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Very long-chain fatty acid-containing lipids rather than sphingolipids per se are required for raft association and stable surface transport of newly synthesized plasma membrane ATPase in yeast.Semantic proximity Read ↗

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