Article
Cell growth-dependent coordination of lipid signaling and glycosylation is mediated by interactions between Sac1p and Dpm1p.
The Journal of cell biology - 17 Jan 2005
Faulhammer Frank, Konrad Gerlinde, Brankatschk Ben, Tahirovic Sabina, Knödler Andreas, Mayinger Peter
Abstract excerpt
The integral membrane lipid phosphatase Sac1p regulates local pools of phosphatidylinositol-4-phosphate (PtdIns(4)P) at endoplasmic reticulum (ER) and Golgi membranes. PtdIns(4)P is important for Golgi trafficking, yet the significance of PtdIns(4)P for ER function is unknown. It also remains unknown how localization of Sac1p to distinct organellar membranes is mediated. Here, we show that a COOH-terminal region...
Topics
- Blotting, Western
- Cathepsin A
- Cell Division
- Centrifugation, Density Gradient
- Endoplasmic Reticulum
- Glucose
- Glycosylation
- Golgi Apparatus
- Green Fluorescent Proteins
- Guanine Nucleotide Exchange Factors