Article

Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol

2024-11-05

Abstract excerpt

Sac1 is a conserved phosphoinositide phosphatase, whose loss-of-function compromises cell and organism viability. Here, we employed acute auxin-inducible Sac1 degradation to identify its immediate downstream effectors in human cells. Most of Sac1 was degraded in ∼1 h, paralleled by increased PI(4)P and decreased cholesterol in the trans-Golgi network (TGN) during the following hour, and superseded by Golgi fragmen...

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Literature Corpus work: 97ae6cae-4944-5ff7-a203-7852bef7f3e0
DOI: 10.1101/2024.11.04.621832

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