Article
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response.
Nature genetics - 1 Nov 2007
Gerdes Jantje M, Liu Yangfan, Zaghloul Norann A, Leitch Carmen C, Lawson Shaneka S, Kato Masaki, Beachy Philip A, Beales Philip L, DeMartino George N, Fisher Shannon, Badano Jose L, Katsanis Nicholas
Abstract excerpt
Primary cilia and basal bodies are evolutionarily conserved organelles that mediate communication between the intracellular and extracellular environments. Here we show that bbs1, bbs4 and mkks (also known as bbs6), which encode basal body proteins, are required for convergence and extension in zebrafish and interact with wnt11 and wnt5b. Suppression of bbs1, bbs4 and mkks transcripts results in stabilization of...
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