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Article

Daptomycin inoculum effects and mutant prevention concentration with Staphylococcus aureus.

The Journal of antimicrobial chemotherapy - 1 Dec 2007

Quinn Brian, Hussain Syed, Malik Muhammad, Drlica Karl, Zhao Xilin

Abstract excerpt

BACKGROUND: Antimutant activity of antimicrobials can be estimated by comparing drug pharmacokinetics with mutant prevention concentration (MPC). Large bacterial inocula known to reduce susceptibility have not been studied for effects on MPC determination. METHODS: Staphylococcus aureus inoculum size was varied with solid and liquid media containing daptomycin and Ca(2+), a cation expected to lower inoculum...

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Identifiers

PMID: 17905797
DOI: 10.1093/jac/dkm375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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