Article
Mutant prevention concentrations of daptomycin for Enterococcus faecium clinical isolates.
International journal of antimicrobial agents - 1 Oct 2016
Sinel Clara, Jaussaud Clara, Auzou Michel, Giard Jean-Christophe, Cattoir Vincent
Abstract excerpt
Owing to the emergence of vancomycin-resistant Enterococcus faecium, treatment of enterococcal infections has become challenging. Although spontaneous in vitro resistance frequencies are low, the emergence of resistance is increasingly reported during daptomycin therapy. The mutant selection window (MSW), comprised between the minimum inhibitory concentration (MIC) and the mutant prevention concentration (MPC),...
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