An evaluation of the evolution of the gene structure of dystroglycan.

doi:10.1186/s13104-016-2322-x

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Article

An evaluation of the evolution of the gene structure of dystroglycan.

BMC research notes - 3 Jan 2017

Brancaccio Andrea, Adams Josephine C

Abstract excerpt

BACKGROUND: Dystroglycan (DG) is an adhesion receptor complex composed of two non-covalently associated subunits, transcribed from a single gene. The extracellular α-DG is highly and heterogeneously glycosylated and binds with high affinity to laminins, and the transmembrane β-DG binds intracellular dystrophin. Multiple cellular functions have been proposed for DG, notwithstanding that its role in skeletal muscle...

Topics

Animals
Computer Simulation
Cytoplasm
Dystroglycans
Evolution, Molecular
Exons
Glycosylation
Humans
Introns
Laminin
Muscle, Skeletal
Phenotype
Phylogeny
Protein Domains
Software
Species Specificity

Source

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Identifiers

PMID: 28057052
DOI: 10.1186/s13104-016-2322-x
PMCID: PMC5216574

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