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Article

Synthesis and antiviral activity of new dimeric inhibitors against HIV-1.

Bioorganic & medicinal chemistry - 1 Jan 2008

Danel Krzysztof, Larsen Louise M, Pedersen Erik B, Sanna Giuseppina, La Colla Paolo, Loddo Roberta

Abstract excerpt

This paper describes the synthesis and the antiviral activities of dimeric compounds derived from homo and asymmetric combinations of N-1 propynyloxymethyl analogues 1a,b of MKC-442, an N-1 4-iodobenzyloxymethyl analogue of TNK-651 5, potent contraceptive norgestrel and AZT. They were obtained by Sonogashira reaction, 'click' chemistry or Pd-catalyzed oxidative coupling. The iodo precursor 5 turned out as a...

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Identifiers

PMID: 17904371
DOI: 10.1016/j.bmc.2007.09.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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