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Article

Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity.

Journal of medicinal chemistry - 15 Dec 2005

Manetti Fabrizio, Esté José A, Clotet-Codina Imma, Armand-Ugón Mercedes, Maga Giovanni, Crespan Emmanuele, Cancio Reynel, Mugnaini Claudia, Bernardini Cesare, Togninelli Andrea, Carmi Caterina, Alongi Maddalena, Petricci Elena, Massa Silvio, Corelli Federico, Botta Maurizio

Abstract excerpt

A simple and efficient methodology for the parallel solution-phase synthesis has been set up to obtain a series of thiouracils, in turn selectively S-benzylated under microwave irradiation to give new S-DABOs. Biological screening led to the identification of compounds with nanomolar activity toward both the highly purified recombinant human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) enzyme...

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Share to Anti-HIV Agents
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16335924
DOI: 10.1021/jm050744t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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