Article
Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs.
Bioorganic & medicinal chemistry - 1 Sept 2011
Gu Shuang-Xi, He Qiu-Qin, Yang Shi-Qiong, Ma Xiao-Dong, Chen Fen-Er, De Clercq Erik, Balzarini Jan, Pannecouque Christophe
Abstract excerpt
A series of 26 diarylpyrimidines, characterized by the hydroxymethyl linker between the left wing benzene ring and the central pyrimidine, were synthesized and evaluated for in vitro anti-HIV activity. Most of the compounds exhibited moderate to excellent activities against wild-type HIV-1. Among them, compound 10i, bearing a chlorine atom at the C-2 position of left benzene ring, was the best congener and showed...
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