Article
Novel [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2" -dioxide) derivatives with anti-HIV-1 and anti-human-cytomegalovirus activity.
Journal of medicinal chemistry - 24 Feb 2005
de Castro Sonia, Lobatón Esther, Pérez-Pérez María-Jesús, San-Félix Ana, Cordeiro Alessandra, Andrei Graciela, Snoeck Robert, De Clercq Erik, Balzarini Jan, Camarasa María-José, Velázquez Sonsoles
Abstract excerpt
New [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-d-ribofuranosyl]-3'-spiro-5' '-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives substituted at the 4' '-amino group of the spiro moiety with different carbonyl functionalities have been designed and synthesized. Various synthetic procedures, on the scarcely studied reactivity of the 3'-spiroaminooxathioledioxide moiety, have been explored. The...
Topics
- Anti-HIV Agents
- Antiviral Agents
- Cell Line
- Cytomegalovirus
- Drug Resistance, Viral
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Mutation
- Reverse Transcriptase Inhibitors
- Spiro Compounds
- Structure-Activity Relationship