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Article

Design and synthesis of conformationally constrained inhibitors of non-nucleoside reverse transcriptase.

Journal of medicinal chemistry - 24 Nov 2011

Gomez Robert, Jolly Samson J, Williams Theresa, Vacca Joseph P, Torrent Maricel, McGaughey Georgia, Lai Ming-Tain, Felock Peter, Munshi Vandna, Distefano Daniel, Flynn Jessica, Miller Mike, Yan Youwei, Reid John, Sanchez Rosa, Liang Yuexia, Paton Brenda, Wan Bang-Lin, Anthony Neville

Abstract excerpt

Highly active antiretroviral therapy (HAART) significantly reduces human immunodeficiency virus (HIV) viral load and has led to a dramatic decrease in acquired immunodeficiency syndrome (AIDS) related mortality. Despite this success, there remains a critical need for new HIV therapies to address...

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Identifiers

PMID: 21985673
DOI: 10.1021/jm2010173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21985673-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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