Article
Design and synthesis of conformationally constrained inhibitors of non-nucleoside reverse transcriptase.
Journal of medicinal chemistry - 24 Nov 2011
Gomez Robert, Jolly Samson J, Williams Theresa, Vacca Joseph P, Torrent Maricel, McGaughey Georgia, Lai Ming-Tain, Felock Peter, Munshi Vandna, Distefano Daniel, Flynn Jessica, Miller Mike, Yan Youwei, Reid John, Sanchez Rosa, Liang Yuexia, Paton Brenda, Wan Bang-Lin, Anthony Neville
Abstract excerpt
Highly active antiretroviral therapy (HAART) significantly reduces human immunodeficiency virus (HIV) viral load and has led to a dramatic decrease in acquired immunodeficiency syndrome (AIDS) related mortality. Despite this success, there remains a critical need for new HIV therapies to address the emergence of drug resistant viral strains. Next generation NNRTIs are sought that are effective against these...
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