Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1.

doi:10.1021/jm040838n

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Article

Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1.

Journal of medicinal chemistry - 24 Mar 2005

Guillemont Jerome, Pasquier Elisabeth, Palandjian Patrice, Vernier Daniel, Gaurrand Sandrine, Lewi Paul J, Heeres Jan, de Jonge Marc R, Koymans Lucien M H, Daeyaert Frits F D, Vinkers Maarten H, Arnold Eddy, Das Kalyan, Pauwels Rudi, Andries Koen, de Béthune Marie-Pierre, Bettens Eva, Hertogs Kurt, Wigerinck Piet, Timmerman Philip, Janssen Paul A J

Abstract excerpt

This paper reports the synthesis and the antiviral properties of new diarylpyrimidine (DAPY) compounds as nonnucleoside reverse transcriptase inhibitors (NNRTIs). The synthesis program around this new DAPY series was further optimized to produce compounds displaying improved activity against a panel of eight clinically relevant single and double mutant strains of human immunodeficiency virus type 1 (HIV-1).

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Identifiers

PMID: 15771449
DOI: 10.1021/jm040838n

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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