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Article

Genome-wide association with select biomarker traits in the Framingham Heart Study.

BMC medical genetics - 19 Sept 2007

Benjamin Emelia J, Dupuis Josée, Larson Martin G, Lunetta Kathryn L, Booth Sarah L, Govindaraju Diddahally R, Kathiresan Sekar, Keaney John F, Keyes Michelle J, Lin Jing-Ping, Meigs James B, Robins Sander J, Rong Jian, Schnabel Renate, Vita Joseph A, Wang Thomas J, Wilson Peter W F, Wolf Philip A, Vasan Ramachandran S

Abstract excerpt

BACKGROUND: Systemic biomarkers provide insights into disease pathogenesis, diagnosis, and risk stratification. Many systemic biomarker concentrations are heritable phenotypes. Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations. METHODS: We examined the association of Affymetrix...

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PMID: 17903293
DOI: 10.1186/1471-2350-8-S1-S11
PMCID: PMC1995615

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