A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins.

doi:10.7554/eLife.105314

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Article

A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins.

eLife - 27 Aug 2026

Kelpsch Daniel J, Zhang Liyun, Thierer James H, Rivera Cruz Adrian G, Koren Kobe, Kumar Urmi, Lin Yuki, Hensley Monica R, Sohn Mira, Liu Jun O, Lectka Thomas, Mumm Jeff S, Farber Steven A

Abstract excerpt

Lipoproteins are essential for lipid transport in all bilaterians. A single Apolipoprotein B (ApoB) molecule is the inseparable structural scaffold of each ApoB-containing lipoprotein (B-lps), which are responsible for transporting lipids to peripheral tissues. The cellular mechanisms that regulate ApoB and B-lp production, secretion, transport, and degradation remain to be fully defined. In humans, elevated...

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Apolipoproteins B
Atherosclerosis
Drug Evaluation, Preclinical
Hepatocyte Nuclear Factor 4
Lipoproteins
Phenotype

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PMID: 42657783
DOI: 10.7554/eLife.105314
PMCID: PMC13521566

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