Article

MicroRNA-541-3p alters lipoproteins to reduce atherosclerosis by degrading Znf101 and Casz1 transcription factors

2023-11-03

Abstract excerpt

High apoB-containing low-density lipoproteins (LDL) and low apoA1-containing high-density lipoproteins (HDL) are associated with atherosclerosis. In search of a molecular regulator that could simultaneously and reciprocally control both LDL and HDL levels, we screened a microRNA (miR) library using human hepatoma Huh-7 cells. We identified miR-541-3p that both decreases apoB and increases apoA1 expression by induc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5433d3bb-c2c5-56b7-b93b-5e2efa1ec09e
DOI: 10.1101/2023.11.01.565110

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-541-3p alters lipoproteins to reduce atherosclerosis by degrading Znf101 and Casz1 transcription factorsDOI 10.1101/2023.11.01.565110Read

Precision Regulation of LDL Metabolism: Epigenetic and Genetic Approaches Targeting LDLR, APOB, and PCSK9Semantic proximity Read

Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin responseSemantic proximity Read

The Regulation of Reverse Cholesterol Transport and Cellular Cholesterol Homeostasis by MicroRNAsSemantic proximity Read

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular diseaseSemantic proximity Read

SR-B1 and PDZK1: partners in HDL regulation.Semantic proximity Read

MicroRNA-99a-5p alleviates atherosclerosis via regulating Homeobox A1Semantic proximity Read

Profile of Surrounding MicroRNAs in Low Density Lipoprotein UptakeSemantic proximity Read

IDOL deficiency inhibits cholesterol-rich diet-induced atherosclerosis in rabbitsSemantic proximity Read

A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption.Semantic proximity Read

MicroRNA-758 Regulates Cholesterol Efflux Through Posttranscriptional Repression of ATP-Binding Cassette Transporter A1Semantic proximity Read

The Mechanisms of miR-638/StarD10 in HDL MetabolismSemantic proximity Read

Treating low HDL--from bench to bedside.Semantic proximity Read