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Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome

13 Feb 2010

Abstract excerpt

Trisomy of human chromosome 21 (Hsa21) results in Down syndrome (DS), a disorder that affects many aspects of physiology, including hematopoiesis. DS children have greatly increased rates of acute lymphoblastic leukemia and acute megakaryoblastic leukemia (AMKL); DS newborns present with transient myeloproliferative disorder (TMD), a preleukemic form of AMKL. TMD and DS-AMKL almost always carry an acquired...

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PMID: 20154221
DOI: 10.1182/blood-2009-06-227629

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