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Article

Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer.

Journal of cancer research and clinical oncology - 1 Feb 2004

Tsukino Hiromasa, Kuroda Yoshiki, Nakao Hiroyuki, Imai Hirohisa, Inatomi Hisato, Osada Yukio, Katoh Takahiko

Abstract excerpt

PURPOSE: Arylamines are suspected to be the primary causative agent of urothelial cancer in tobacco smoke. In the human liver, arylamines are N-hydroxylated by a cytochrome P450 (CYP)1A2-catalyzed reaction, which produces a substrate for O-esterification that can be catalyzed by N-acetyltransferases (NAT) or sulfotransferases (SULT). Recently, several polymorphisms of CYP1A2, SULT1A1, and NAT2 that affect their...

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Source

Identifiers

PMID: 14648207
DOI: 10.1007/s00432-003-0512-0

Genes

NAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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