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Article

Strong nuclear factor-?B-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic alzheimer's disease superior temporal lobe neocortex

1 Sept 1998

Abstract excerpt

Cyclooxygenase-2 (COX-2; EC 1.14.99.1) RNA message abundance in 25 control and Consortium to Establish a Registry for Alzheimer's Disease (CERAD)-confirmed sporadic Alzheimer's disease (AD) brains is remarkably heterogeneous when compared with 55 other AD brain RNA message levels that were previously characterized (Lukiw and Bazan: J Neurosci Res 50:937-945, 1997). Examination of nuclear protein extracts (NPXTs)...

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PMID: 9726429
DOI: 10.1002/(sici)1097-4547(19980901)53:5<583::aid-jnr8>3.0.co;2-5

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