Changes of neurofilament light chain in patients with alcohol dependence following withdrawal and the genetic effect from ALDH2 Polymorphism.

doi:10.1007/s00406-023-01635-5

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Article

Changes of neurofilament light chain in patients with alcohol dependence following withdrawal and the genetic effect from ALDH2 Polymorphism.

European archives of psychiatry and clinical neuroscience - 1 Mar 2024

Huang Ming-Chyi, Tu Hsueh-Yuan, Chung Ren-Hua, Kuo Hsiang-Wei, Liu Tung-Hsia, Chen Che-Hong, Mochly-Rosen Daria, Liu Yu-Li

Abstract excerpt

Neurofilament light chain (NFL), as a measure of neuroaxonal injury, has recently gained attention in alcohol dependence (AD). Aldehyde dehydrogenase 2 (ALDH2) is the major enzyme which metabolizes the alcohol breakdown product acetaldehyde. An ALDH2 single nucleotide polymorphism (rs671) is associated with less ALDH2 enzyme activity and increased neurotoxicity. We examined the blood NFL levels in 147 patients...

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Identifiers

PMID: 37314537
DOI: 10.1007/s00406-023-01635-5
PMCID: PMC10719424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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