Article
The positive feedback loop of NHE1-ERK phosphorylation mediated by BRAFV600E mutation contributes to tumorigenesis and development of glioblastoma.
Biochemical and biophysical research communications - 15 Jan 2022
Li Yuhui, Li Dan, Liu Yankun, Wang Shuqing, Sun Mingyang, Zhang Zhongyuan, Zheng Xuan, Li Jingwu, Li Yufeng
Abstract excerpt
The v-raf murine sarcoma viral oncogene homolog B1 (BRAF) activating mutation V600E (BRAFV600E) is involved in glioblastoma multiforme (GBM). Na/H exchanger 1 (NHE1), a main pH regulator affecting cell microenvironment, is hyper-expressed in GBM. However, the relationship between BRAFV600E signal pathway and NHE1 in GMB cells remains unclear. This study found that NHE1 was a downstream target of BRAFV600E and an...
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