Article
Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development.
Human molecular genetics - 15 Dec 2007
Bian Yansong, Knobloch Thomas J, Sadim Maureen, Kaklamani Virginia, Raji Adekunle, Yang Guang-Yu, Weghorst Christopher M, Pasche Boris
Abstract excerpt
TGFBR1*6A is a common hypomorphic variant of the type I transforming growth factor (TGF)-beta receptor (TGFBR1), which transduces TGF-beta growth inhibitory signals less effectively than TGFBR1. Recent studies suggest that TGFBR1*6A confers a selective growth advantage to both normal appearing an...
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