Article
TGFBR1*6A enhances breast cancer development through downregulation of p27
2023-06-26
Abstract excerpt
<title>Abstract</title> <p>TGFBR1*6A (rs1466445) is a common low penetrance tumor susceptibility allele with a minor allelic frequency of 0.051. Several meta-analyses show that TGFBR1*6A is associated with breast cancer risk with an OR ranging from 1.15 to 1.30. We developed a novel knockin mouse model of TGFBR1*6A to study mammary cancer development and progression in MMTVneu mice. Here we show that TGFBR1*6A ac...
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Identifiers and source
- Literature Corpus work
- db46348b-2b44-5699-ba20-25bebfae7ffb
- DOI
- 10.21203/rs.3.rs-2997389/v1