Article
Is erythropoietin gene a modifier factor in amyotrophic lateral sclerosis?
Neurobiology of aging - 1 May 2009
Ghezzi Serena, Del Bo Roberto, Scarlato Marina, Nardini Martina, Carlesi Cecilia, Prelle Alessandro, Corti Stefania, Mancuso Michelangelo, Briani Chiara, Siciliano Gabriele, Murri Luigi, Bresolin Nereo, Comi Giacomo Pietro
Abstract excerpt
To investigate the role of erythropoietin (EPO) as genetic determinant in the susceptibility to sporadic amyotrophic lateral sclerosis (SALS). We sequenced a 259-bp region spanning the 3'hypoxia-responsive element of the EPO gene in 222 Italian SALS patients and 204 healthy subjects, matched for age and ethnic origin. No potentially causative variation was detected in SALS subjects; in addition, two polymorphic...
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