Article
Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population.
Journal of the neurological sciences - 15 Jul 2007
Corrado Lucia, Battistini Stefania, Penco Silvana, Bergamaschi Laura, Testa Lucia, Ricci Claudia, Giannini Fabio, Greco Giuseppe, Patrosso Maria Cristina, Pileggi Simona, Causarano Renzo, Mazzini Letizia, Momigliano-Richiardi Patricia, D'Alfonso Sandra
Abstract excerpt
Potentially causative missense variations in the ANG gene and a positive association with the synonymous rs11701-G substitution was detected mainly in Irish and Scottish ALS patients. We screened 262 Italian SOD1 negative ALS patients (250 sporadic) and 415 matched controls for sequence variations in the coding, 3'/5' UTR and 5' flanking (642 bp) regions of the ANG gene. We identified 53 sequence variations of...
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