Article
Prevalence of functional haplotypes of the peptidylarginine deiminase citrullinating enzyme gene in patients with rheumatoid arthritis: no influence of the presence of anti-citrullinated peptide antibodies.
Clinical and experimental rheumatology - 1 Jan 2000
Faragó B, Talián G C, Maász A, Magyari L, Horvatovich K, Kovács B, Cserép V, Kisfali P, Kiss C G, Czirják L, Melegh B
Abstract excerpt
OBJECTIVE: Citrullinated peptides produced by enzymatic deimination of arginine residues in proteins by peptidylarginine deiminases are of particular interest in the pathogenesis of rheumatoid arthritis (RA). One type of citrullinated protein - the cyclic citrullinated peptide - is the target of the anti-cyclic citrullinated peptide antibody, the most sensitive and specific autoantibody in RA. The...
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