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Article

Genetic instrumental variable analysis: time to call mendelian randomization what it is. The example of alcohol and cardiovascular disease.

European journal of epidemiology - 1 Feb 2020

Mukamal Kenneth J, Stampfer Meir J, Rimm Eric B

Abstract excerpt

In recent years, epidemiologists have increasingly sought to employ genetic data to identify 'causal' relationships between exposures of interest and various endpoints - an instrumental variable approach sometimes termed Mendelian randomization. However, this approach is subject to all of the limitations of instrumental variable analysis and to several limitations specific to its genetic underpinnings, including...

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PMID: 31761964
DOI: 10.1007/s10654-019-00578-3

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