Article
Molecular pathogenesis of cutaneous melanocytic neoplasms.
Annual review of pathology - 1 Jan 2009
Ibrahim Nageatte, Haluska Frank G
Abstract excerpt
Melanoma is the deadliest form of skin cancer without an effective treatment. An understanding of the genetic basis of melanoma has recently shed light on some of the mechanisms of melanomagenesis. This review explores the major genes involved in familial and sporadic cutaneous melanoma with an emphasis on CDKN2A, CDK4, MC1R, and MAPK pathway targets (e.g., RAS and BRAF), apoptosis regulators (e.g., BCL-2, AKT,...
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